Regulatory &
Systems Genomics
Satellite Meeting

Thessaloniki, Greece May 25, 2026 RECOMB 2026 ↗

Welcome to the RECOMB-RSG 2026. This satellite meeting brings together researchers to discuss emerging frontiers in the algorithmic, mathematical, and statistical study of gene regulation and systems biology.

The program will feature invited talks and contributed presentations. A key focus is on scientific discussion: we strongly encourage participants to submit and present preprints or recently published work. This approach allows new results to be discussed in detail, critiqued constructively, and built upon collaboratively.

Contributions on any theoretical and/or empirical approach to regulatory systems are welcome. Topics of interest include, but are not limited to:

  • Gene Regulatory Networks
  • Single-cell Multi-omics
  • Spatial Transcriptomics
  • Chromatin & Epigenomics
  • Deep Learning in Genomics
  • Virtual Cell Models
  • Evolutionary Systems Biology
  • Perturbation Biology
  • Machine Learning in Genomics
  • Multi-modal Integration

Program

Monday, May 25, 2026. Schedule is subject to minor changes.

Keynote
Talk (20 min)
Lightning (10 min)
Break
Monday, May 25
09:25 – 09:30
Welcome Welcome speech
09:30 – 10:20
Keynote — Ben Raphael, PhD (Princeton University) 40 min + 10 min Q&A
10:20 – 10:40
Chuhanwen Sun and Yi Zhang STHD: probabilistic cell typing of single Spots in whole Transcriptome spatial data with High Definition
10:40 – 11:00
Haoyu Wang, Brittany Cody, Manuel Saavedra, Lanuza Faccioli, Rodrigo Florentino, Alejandro Soto-Gutierrez and Hatice Ulku Osmanbeyoglu DGAT: A Dual-Graph Attention Network for Inferring Spatial Protein Landscapes from Transcriptomics
11:00 – 11:40
Midmorning coffee break
11:40 – 12:00
Seokmin Ha and Bonnie Berger Inferring Direct Causal Regulation in Branching Lineages via Geometric Deconfounding
12:00 – 12:20
Elizabeth Gilfeather, Maria Chikina and Dennis Kostka When Less Is Enough: Low-Rank Structure in DNA Sequence-to-Function Models
12:20 – 12:40
Jieni Hu, Julianne Fetter, David Ryan Koes and Maria Chikina InfluenceNet: Encoding Motif Influence for Interpretable Modeling of Cis-Regulatory Syntax
12:40 – 12:50
Noam Shimshoviz, Safwan Butto and Yaron Orenstein NPBIP: Predicting Binding Preferences of Uncharacterized Nucleic-Acid-Binding Proteins
12:50 – 13:00
Fabian Woller, Paul Martini, Souptik Sen, David B. Blumenthal and Anne Hartebrodt SignifiKANTE: Efficient P-value computation for gene regulatory networks
13:00 – 14:30
Lunch break
14:30 – 14:50
Abrar Rahman Abir, Sajib Acharjee Dip and Liqing Zhang CFM-GP: Unified Conditional Flow Matching to Learn Gene Perturbation Across Cell Types
14:50 – 15:10
Hechen Li and Xiuwei Zhang scModCompare: Disentangling Shared Identity and Modality-Specific Regulatory Programs in Multimodal Single-Cell Data
15:10 – 15:30
Hui Cheng, Yunhao Qiao, Yufan Feng, Yuyang Wei, Jinpu Cai, Xinzhu Jiang, Qiuyu Lian and Hongyi Xin VeloTrace Reconciles Divergent Velocity and Trajectory in Single-cell Transcriptomics with Deep Neural ODE
15:30 – 15:40
Anna Möller, Miriam Schnitzerlein, Eric Greto, Vasily Zaburdaev, Stefan Uderhardt and David B. Blumenthal Quantifying distribution shifts in single-cell data with scXMatch
15:40 – 15:50
Kristina Sungeun Song, Marianne Cyr, Laurence Faucher-Giguère, Bernice Yeo Hwee Ting, Vivian Kaiyan Seow, Gabrielle Deschamps-Francoeur, Sherif Abou Elela and Michelle S. Scott snoFlake: A network model for discovering novel snoRNA-RBP regulatory complexes in human post-transcriptional regulation
15:50 – 16:00
Sobhan Shukueian Tabrizi, Helyasadat Hashemi Aghdam and A. Ercument Cicek RNA–X: Modeling RNA interactions to design binder RNA and simultaneously target multiple molecules of different types
16:00 – 16:40
Afternoon coffee break
16:40 – 17:00
Ruyi Chen, Nathan Palpant, Gabriel Foley and Mikael Boden Coupling codon and protein constraints decouples drivers of variant pathogenicity
17:00 – 17:20
Pia Keukeleire, Coline Arnould, Martin Kircher and Nadav Ahituv Simultaneously characterizing promoter interactions and regulatory activity using Capture-C MPRA
17:20 – 17:25
Closing remarks
17:30 – 19:00
Poster session
20:00
Dinner

Venue

RECOMB-RSG will be held at the Nikolaos Germanos Congress Center in Thessaloniki.

Venue HELEXPO: Emilios Riadis Multipurpose Hall

St. Egnatia 154
546 46 Thessaloniki, Greece

Venue Details and Hotels →

Committees


Program Committee
Wei Wang University of California, San Diego Serdar Bozdag University of North Texas James Costello University of Colorado Anschutz Medical Campus Raluca Gordan UMass Chan Medical School Maxwell Libbrecht Simon Fraser University Shaun Mahony The Pennsylvania State University Pei-Chen Peng Cedars-Sinai Medical Center Peng Qiu Georgia Institute of Technology Pavel Sumazin Baylor College of Medicine Kevin Yip Sanford Burnham Prebys Medical Discovery Institute Ye Zheng The University of Texas MD Anderson Cancer Center Jishnu Das University of Pittsburgh Amin Emad McGill University Ivan G. Costa RWTH Aachen University Anthony Gitter University of Wisconsin–Madison Dennis Kostka University of Pittsburgh T. M. Murali Virginia Tech Andreas Pfenning Carnegie Mellon University Derek Reiman University of Chicago Marcel Schulz Goethe University Frankfurt Yi Zhang Duke University Xiuwei Zhang Georgia Institute of Technology

History

The Regulatory & Systems Genomics (RSG) meeting has been a part of the computational biology community for over two decades. Started in 2004 as a satellite meeting of RECOMB, it has traveled across the US and the world, fostering collaboration and innovation.

From 2007 to 2024, the meeting was held in combination with the ISCB DREAM Challenges. View 2024 Conference →